2020, Vol. 1, Issue 2, Part A
Physiology and pathology of innate immune response against pathogens
Author(s): Alireza Heidari, Elena Locci and Silvia Raymond
Abstract: This study has discovered a new mechanism that involves inhibiting the organelle, the lysosome, and dormant that cell. This opens the way for lysosomes to potentially be used as a therapeutic target. Tens of thousands of people around the world receive bone marrow transplants each year to help treat leukemia. High doses of chemotherapy are used to quickly kill cancer cells, but they also kill the stem cells needed to reproduce healthy blood. Stem cell transplantation is used to regenerate a patient's healing blood source, but finding the right donor can be challenging, especially in different ethnic communities where the donor list may not be extensive or non-existent. Stem cells in cord blood are of considerable value as additional donor sources, but the number of stem cells is often too small for an adult recipient. Understanding how stem cells are activated and proliferated in a controlled manner can greatly benefit cord blood. The ability to control stem cell activation may also be helpful in situations where stem cells are improperly activated due to disease, inflammation, or drug treatment, and help maintain sleep. Learning how to maintain blood stem cells is essential. If that stem cell is activated improperly, it can have serious consequences for the blood system, because stem cells are not renewable. You have to do everything you can to keep that cell asleep, and one way is to block signals from its surface. It can also be used to help fully understand leukemia stem cells, which mimic normal stem cells and are sometimes able to sleep and escape treatment. It is now interesting to look at these leukemia stem cells and see how this mechanism is regulated. We may notice differences and use them for treatment.
Pages: 36-47 | Views: 507 | Downloads: 193
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How to cite this article:
Alireza Heidari, Elena Locci, Silvia Raymond. Physiology and pathology of innate immune response against pathogens. J Res Chem 2020;1(2):36-47.