2021, Vol. 2, Issue 1, Part A
Antifungal activity of 1, 2, 3-triazoles of 1-Benzyl-4-(phenoxymethyl) derivatives
Author(s): Yogesh Kumar, Vijay Bahadur, Anil Kumar Singh and Poonam Mothsra
Abstract: In order to combat the alarming fungal infections, twenty-nine synthesised novel analogues of 1, 2, 3-triazole were further evaluated for their antifungal activity and cytotoxicity. The 1,2,3- triazole analogs were synthesized by using propyloxy benzene, phenyl or benzyl azide, commercially available copper sulphate, D-Glucose and N, N-diisopropylethylamine [DIPEA (2 mmol)], in THF: H2O (2: 1) by various microwave assisted techniques. Characterisation of the structure was done using spectroscopic techniques 1H-NMR, 13C-NMR, MS and elemental analyses. All synthesized compound showed potent antifungal activity when compared to established drugs voriconazole (VCZ) and fluconazole (FCZ) taken as control. In vitro antifungal activities against five common human pathogenic fungi viz. Candida albicans MTCC 7253, Candida parapsilosis MTCC 7043, Candida haemuloni MTCC 8176, Aspergillus niger MTCC 9652, Aspergillus flavus MTCC 7133. The cytotoxicity of the compounds was also evaluated by using MCF-7 cell lines and IC80 was calculated. This work established the use of analogues of 1, 2, 3-triazole as potent antifungal compounds against the advent of resistant fungal strains.
Pages: 90-93 | Views: 303 | Downloads: 107
Download Full Article: Click Here

How to cite this article:
Yogesh Kumar, Vijay Bahadur, Anil Kumar Singh, Poonam Mothsra. Antifungal activity of 1, 2, 3-triazoles of 1-Benzyl-4-(phenoxymethyl) derivatives. J Res Chem 2021;2(1):90-93.