2021, Vol. 2, Issue 1, Part A
Antimicrobial, antioxidant, cytotoxicity profiles and chemical compositions of ethanolic extracts of Ficus polita and Ficus thonningii plant
Author(s): Muhammad F Yahaya, Sunday A Osemeahon, Mohammed H Shagal, Oliver N Maitera, Peter M Dass and Jibrin M Yelwa
Abstract: Ficus polita and Ficus thonningii Blume are one of the medicinal plants used in the treatment of various diseases traditionally by Lala people of Adamawa State, Nigeria. The present study was conducted with the objectives of evaluating the possible phytochemical components present in the methanol extract of Ficus polita and Ficus thonningii Blume and analyse the effective bioactive compounds using GC-MS. And to evaluate the cytotoxicity, antimicrobial and antioxidant profiles of the plant extracts. The cytotoxicity, anti-microbial and antioxidant activities of plants leaves were carried out using standard methods. Among the compounds found in Ficus polita extract, cis-Vaccenic acid (43.17%) was found with the highest peak area % followed by Oleic Acid (5.01%), 9-Octadecenoic acid, (E)- (4.31%), Corynan-17-ol, 18,19-didehydro-10-methoxy-, acetate (ester) (4.83%), 11-Octadecenoic acid, methyl ester (3.30%), 9-Octadecenoic acid (Z)-, 2-hydroxy-1-(hydroxymethyl) ethyl ester (3.18%), 9,12-Octadecadienoic acid (Z,Z)- (2.26%) and for Ficus thonningii Blume extract, cis-Vaccenic acid (41.11%) was found with the highest peak area % followed by Phenol, 2,5-bis(1,1-dimethylethyl) (9.04%), 8-Octadecenoic acid, methyl ester, (E)- (5.98%), 9-Octadecenoic acid (Z)-, 2,3-dihydroxypropyl ester (5.74%), 9-Octadecenoic acid, (E)- (4.19%), and Oleic Acid (2.57%). The results of the cytotoxicity of the ethanolic extract of the plants showed direct relationship with the mortality rate of the brine shrimp because as the concentration of the plants extracts increases, the value of brine shrimp mortality from 6 - 24 hours also increases. Moderate antimicrobial activity of ethanol extract of Ficus polita and Ficus thonningii Blume leaves were observed against Klebsiella Pneumonia, Escherichia coli, Muti drug resistant Acinetobacter, Pneumonia, Salmonella Typhi and Candida. Antioxidant capacity of these two plants extracts of Ficus polita and Ficus thonningii Blume were determined by DPPH and H2O2 assays. This result indicates the use of Ficus polita and Ficus thonningii Blume in ethno-medicine for the management of different illness.
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How to cite this article:
Muhammad F Yahaya, Sunday A Osemeahon, Mohammed H Shagal, Oliver N Maitera, Peter M Dass, Jibrin M Yelwa. Antimicrobial, antioxidant, cytotoxicity profiles and chemical compositions of ethanolic extracts of Ficus polita and Ficus thonningii plant. J Res Chem 2021;2(1):04-10.
