Journal of Research in Chemistry
2022, Vol. 3, Issue 2, Part A
Synthesis, UV-visible and ADME study of transition metal complexes of 8-Hydroxyquinoline
Author(s): Sanjay R Kale, Monali R Nanaware and Rahul S Bhondwe
Abstract: 8-HQ is a small planer molecule with a lipophilic effect and a metal chelating ability. As a result, 8-HQ and its derivatives hold medicinal properties such as anti-neurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory and antidiabetic. Metal (II), (IV) and (VI) coordination compounds of 8-Hydroxyquinoline were synthesized by stoichiometric reaction between metal (II), (IV) and (VI) with 8-Hydroxyquinoline in molar ratio at (1: 1) and (1:2) [M: 8-HQ] [Where, M= Ni2+, Cu2+, Co2+, Mn2+]. Characterized by using UV-Visible and swiss ADME. In the current implementation the UV-Visible analysis showed different peaks at range 200-800 nm with showed different absorbance respectively. SwissADME study is carried out for different medicinal and chemical factors such as water solubility, drug likeness, physicochemical properties, lipophilicity, pharmacokinetics and medicinal chemistry of different compounds.
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How to cite this article:
Sanjay R Kale, Monali R Nanaware, Rahul S Bhondwe. Synthesis, UV-visible and ADME study of transition metal complexes of 8-Hydroxyquinoline. J Res Chem 2022;3(2):06-10.