2023, Vol. 4, Issue 2, Part B
Efficient synthesis of clopidogrel using magnetically recoverable Fe3O4 nanoparticles via strecker reaction
Author(s): Dr. Aviraboina Siva Prasad and Harshita Gaddipati
Abstract: The significance of magnetic nanoparticles, particularly magnetite (Fe3O4) nanoparticles, in various applications such as medicine and catalysis. The unique magnetic properties of these nanoparticles allow for their efficient immobilization and separation using external magnets, eliminating the need for traditional separation techniques like filtration or centrifugation. Magnetite nanoparticles are explored extensively due to their properties within the inverse spinel structure. The potential applications of Fe3O4 nanoparticles include their role as carriers for targeted drug delivery and contrast agents in magnetic resonance imaging (MRI) due to their biocompatibility, low toxicity, and high saturation magnetization. Additionally, these nanoparticles serve as effective catalysts and catalyst supports. The abstract highlights their magnetic separability in catalytic reactions, enhancing reaction efficiency. The synthesis of α-aminonitriles through the Strecker reaction, a valuable pathway for α-amino acid and heterocyclic compound synthesis. The use of alternative cyanide sources, such as trimethylsilyl cyanide (TMSCN), is emphasized for its practicality and environmental benefits compared to traditional toxic cyanide sources synthesis of clopidogrel (Plavix), a platelet aggregation inhibitor used in the treatment of various cardiovascular conditions.
Pages: 101-107 | Views: 42 | Downloads: 20
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How to cite this article:
Dr. Aviraboina Siva Prasad, Harshita Gaddipati. Efficient synthesis of clopidogrel using magnetically recoverable Fe3O4 nanoparticles via strecker reaction. J Res Chem 2023;4(2):101-107.