2023, Vol. 4, Issue 2, Part B
Synthesis of novel thiazole derivative of Di-substituted N-aryl maleimides and characterized by spectral and analytical techniques
Author(s): Sunita A Chaudhari, Vasant M Patil, Satish M Chavan, Jitendra P Raut, Sambhaji V Patil and Vishwanath R Patil
Abstract:
The compound 1 was reacted with bromine in DMF to obtain dibromo succinimide 2. Compound 2 was reacted with piperidine as a base followed by dehydrohalogenation to obtained monobromo compound 3 through a common enaminone intermediate, further compound 3 on Vilsmeier Haack formylation afforded compound 4 with good yield. The condensation of 2,5-dihydro-2,5-dioxo-1-phenyl-4-(piperidin-1-yl)-1H-pyrrole-3-carbaldehyde 4 with thiosemicarbazide hydrochloride in ethanol in presence of acetic acid furnished compound 5 with 82% yield. The compound 5 react with disubstituted phenacyl bromide 6 a-e to obtained thiazole derivative of Di-substituted N-aryl maleimides 7 a-e with good yield. All the synthesized compounds were well characterised by spectral and analytical techniques.
DOI: 10.22271/reschem.2023.v4.i2b.107
Pages: 118-122 | Views: 633 | Downloads: 290
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How to cite this article:
Sunita A Chaudhari, Vasant M Patil, Satish M Chavan, Jitendra P Raut, Sambhaji V Patil, Vishwanath R Patil. Synthesis of novel thiazole derivative of Di-substituted N-aryl maleimides and characterized by spectral and analytical techniques. J Res Chem 2023;4(2):118-122. DOI: 10.22271/reschem.2023.v4.i2b.107