2024, Vol. 5, Issue 2, Part A
Facile formulation of Cr (III) organo-metallic adduct from natural pomegranate juice: An effective alternative for Cr (III) supplementation
Author(s): Amartya Kumar Gupta, Arijit Goswami, Satirtha sengupta, Rituparna Mukherjee and Nandita Das
Abstract: Trivalent chromium is known for attenuating insulin resistance, lowering plasma cholesterol levels in human body and is used as nutritional supplements. In contrast, hexavalent chromium Cr (VI) is a known hemotoxin, genotoxin and carcinogen. Therefore, oxidation of Cr (III) to Cr (VI) is a serious concern for human health. Unfortunately, the natural oxidation of Cr (III) to Cr (VI) is thermodynamically feasible in both aerobic and mildly anoxic environment. Thus, to get the optimum benefit from Cr (III), it has to be prevented from auto-oxidation to harmful Cr (VI). This study dwells on the preparation of organometallic adduct between Cr(III) with natural pomegranate juice which is known to contain diverse phenolic compounds like punicalagin isomers, ellagic acid derivatives and anthocyanins which are known to be potent antioxidants. These antioxidants prevent the oxidation of Cr (III) to Cr (VI) which is evaluated by oxidative challenges posed by various known oxidants. The prepared adduct is also characterised by various physicochemical techniques viz. chromatography, spectroscopic studies etc. The present study shows that the adduct can successfully inhibit the oxidation of Cr (III) to Cr (VI) in compare to bare Cr (III) compounds which in turn can be used as an effective alternative for Cr (III) supplementation like chromium picolinate, chromium polynicotinate etc.
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How to cite this article:
Amartya Kumar Gupta, Arijit Goswami, Satirtha sengupta, Rituparna Mukherjee, Nandita Das. Facile formulation of Cr (III) organo-metallic adduct from natural pomegranate juice: An effective alternative for Cr (III) supplementation. J Res Chem 2024;5(2):88-93.
