Journal of Research in Chemistry
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P-ISSN: 2709-9415, E-ISSN: 2709-9423

2025, Vol. 6, Issue 1, Part A


Synthesis, characterization and antimicrobial activity of Cr(III), Mn(III), Fe(III), VO(IV) and Th(IV) metal complexes from hydrazone ligand derived from salicyloyl hydrazide


Author(s): Prashant R Mandlik and Pallavi R Deshmukh

Abstract: A new hydrzone ligand derived from condensation of salicyloyl hydrazide with isatin and its Cr(III), Mn(III), Fe(III), VO(IV) and Th(IV) complexes were synthesized. The synthesized compounds were characterized by elemental analysis, magnetic susceptibility, molar conductance, infrared spectra and electronic absorption spectroscopy. Analytical data suggested 1:1 metal: ligand ratio for Cr(III) and Fe(III) complexes whereas, 1:2 metal: ligand ratio for Mn(III), VO(IV) and Th(IV) complexes. The FTIR spectra showed that the ligand acted as monobasic bidentate (ON) and dibasic tridentate (ONO). Molar conductance values of all the synthesized metal complexes in DMSO indicated their nonelectrolytic nature. The analytical and spectroscopic data suggest a square pyramidal geometry for Mn(III) and VO(IV) complexes and an octahedral geometry for Cr(III), Fe(III) and Th(IV) complexes. The observed ESR parameters are in good agreement with the values generally observed for the vanadyl complex with square pyramidal geometry. Various kinetics and thermodynamic parameters are calculated using Freemann-Caroll and Sharp-Wentworth method and on the basis of half decomposition temperature, the thermal stability order of the compounds was found to be Fe(III) > VO(IV) > Mn(III) > Cr(III) > Th(IV) > LH2. The antibacterial as well as antifungal activities of ligand and its metal complexes were evaluated in vitro against gram negative bacteria (Escherichia coli and Pseudomonas) and gram positive bacteria (Staphylococcus aureus and Diplococcus pneumoniae) and two fungi (Candida albicans and Trichophyton rubrum).

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Journal of Research in Chemistry
How to cite this article:
Prashant R Mandlik, Pallavi R Deshmukh. Synthesis, characterization and antimicrobial activity of Cr(III), Mn(III), Fe(III), VO(IV) and Th(IV) metal complexes from hydrazone ligand derived from salicyloyl hydrazide. J Res Chem 2025;6(1):13-22.
Journal of Research in Chemistry
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