2025, Vol. 6, Issue 2, Part A
Eicosanoid pathway regulation by plant-based diets a chemico-biological analysis with focus on Amaranthus
Author(s): Sofia Lindgren
Abstract: Eicosanoids are lipid mediators that regulate diverse physiological and pathological processes, including inflammation, immunity, and carcinogenesis. Their biosynthesis, primarily derived from arachidonic acid metabolism, is strongly influenced by diet. Plant-based diets enriched with bioactive compounds such as flavonoids, polyphenols, and unsaturated fatty acids provide a non-pharmacological means of modulating the eicosanoid pathway. Amaranthus, a nutrient-rich genus widely consumed as both leafy vegetables and pseudocereals, contains squalene, rutin, quercetin, and essential fatty acids with known bioactivity against cyclooxygenase (COX) and lipoxygenase (LOX) enzymes. This study provides a chemico-biological analysis of the relationship between Amaranthus intake and regulation of eicosanoid synthesis. Experimental findings demonstrate that extracts from Amaranthus species inhibit COX-2 activity, reduce leukotriene formation, and suppress downstream prostaglandin E2 production in cellular and animal models. These outcomes suggest that Amaranthus has strong potential as a dietary intervention to mitigate chronic inflammation and cancer progression through biochemical regulation of eicosanoid pathways.
Pages: 68-75 | Views: 56 | Downloads: 15
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How to cite this article:
Sofia Lindgren. Eicosanoid pathway regulation by plant-based diets a chemico-biological analysis with focus on Amaranthus. J Res Chem 2025;6(2):68-75.
