2025, Vol. 6, Issue 2, Part B
Benzothiadiazines in modern drug discovery: Structural insights and therapeutic applications
Author(s): B Vanathi, P Perumal, A Chandru, K Karthick, S Sowmiya Sri, K Mehavarshini, N Mohanram, M Nithya and GR Kaviyavikashini
Abstract: Benzothiadiazine derivatives constitute a versatile class of heterocyclic compounds with broad pharmacological potential, ranging from classical thiazide diuretics to emerging multifunctional therapeutics. The 1,2,4-benzothiadiazine 1,1-dioxide scaffold serves as the structural foundation for diverse biological activities, including diuretic, antihypertensive, antiviral, anticancer, antidiabetic, and neuroactive effects. Clinically established agents such as hydrochlorothiazide and diazoxide underscore their therapeutic importance, while newer derivatives show notable promise as antiviral agents against HCMV, HCV, and HIV, as well as neuropharmacological modulators acting positively on AMPA and kainate receptors. Recent studies also reveal potent anticancer effects, antioxidant activity, and aldose reductase inhibition, supporting their utility in addressing metabolic disorders and complications of diabetes. Insights from pharmacokinetic studies and molecular dynamics simulations further elucidate their membrane interactions, absorption, and distribution, informing future drug design strategies. This review summarizes key pharmacological activities, structure–activity relationships, and physicochemical insights of benzothiadiazines, emphasizing their evolution from traditional diuretics to a platform for multifunctional drug discovery.
Pages: 104-108 | Views: 49 | Downloads: 17
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How to cite this article:
B Vanathi, P Perumal, A Chandru, K Karthick, S Sowmiya Sri, K Mehavarshini, N Mohanram, M Nithya, GR Kaviyavikashini. Benzothiadiazines in modern drug discovery: Structural insights and therapeutic applications. J Res Chem 2025;6(2):104-108.
