2026, Vol. 7, Issue 1, Part B

In the present investigation, the synthesis and antimicrobial evaluation of heterocyclic fused ring system via Claisen-Schmidt condensation using Vilsmeier-Haack reagent. The heterocyclic substrate is prepared by treatment of acetophenone with phenylhydrazine. The phenylhydrazone derivatives upon treatment with DMF-POCl₃ afforded 3-aryl-1-phenylpyrazol-4-carboxaldehyde. Subsequently the Claisen-Schmidt condensation of 3-aryl-1-phenylpyrazol-4-carboxaldehyde with 3-acetylpyridine in methanolic NaOH afforded the corresponding aldehyde. The structures of these newly synthesized compounds were characterized by ¹H NMR spectroscopic studies. All the synthesized compounds were screened for their antimicrobial evaluation. Some of the compounds exhibited promising antimicrobial activity. From the present study it may be concluded that synthesized compounds are fruitful in terms of their structural novelty and marked biological activities.