2024, Vol. 5, Issue 1, Part A

There is potent and simple method of synthesis of a new class of heterocycles called isoxazolidines. The synthesis is achieved here by 1, 3 dipolar cycloaddition with α-Glutaraldehyde-N-aryl nitrone acting as a dipole and cinnamaldehyde acting as a dipolarophile. Reaction of α- Glutaraldehyde-N-aryl nitrone and different substituted cinnamaldehydes, new isoxazolidines has been precisely synthesized with yields ranging from 85 to 90 percent. The synthesized heterocyclic compounds are characterized by UV, FT-IR and NMR techniques. The isoxazolidines thus synthesized have particular antibacterial properties which shown biologically active and detained bacterial activity amongst Bacillus Marisflavi and Pseudomonas aeruginosa.