2024, Vol. 5, Issue 1, Part A
1, 3 - Dipolar cycloaddition of α- Glutaraldehyde - N - Aryl nitrone with cinnamaldehyde: An efficient synthesis of novel Isoxazolidines and evaluation of its antibacterial activity
Author(s): P Sivadharani and SR Jayapradha
Abstract:
There is potent and simple method of synthesis of a new class of heterocycles called isoxazolidines. The synthesis is achieved here by 1, 3 dipolar cycloaddition with α-Glutaraldehyde-N-aryl nitrone acting as a dipole and cinnamaldehyde acting as a dipolarophile. Reaction of α- Glutaraldehyde-N-aryl nitrone and different substituted cinnamaldehydes, new isoxazolidines has been precisely synthesized with yields ranging from 85 to 90 percent. The synthesized heterocyclic compounds are characterized by UV, FT-IR and NMR techniques. The isoxazolidines thus synthesized have particular antibacterial properties which shown biologically active and detained bacterial activity amongst Bacillus Marisflavi and Pseudomonas aeruginosa.
Pages: 13-18 | Views: 636 | Downloads: 313
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How to cite this article:
P Sivadharani, SR Jayapradha. 1, 3 - Dipolar cycloaddition of α- Glutaraldehyde - N - Aryl nitrone with cinnamaldehyde: An efficient synthesis of novel Isoxazolidines and evaluation of its antibacterial activity. J Res Chem 2024;5(1):13-18.